Pharmacological Strategies to Retard Cardiovascular Aging

Pharmacological Strategies to Retard Cardiovascular Aging.

Aging is the major risk factor for cardiovascular diseases, which are the leading cause of death in the United States. Traditionally, the effort to prevent cardiovascular disease has been focused on addressing the conventional risk factors, including hypertension, hyperglycemia, hypercholesterolemia, and high circulating levels of triglycerides. However, recent preclinical studies have identifi...

Non-pharmacological strategies in cardiovascular prevention: 2011 highlights.

The clinical efficacy of cardiac rehabilitation programs is clearly recognized. Yet, as regards the three main currently employed strategies (exercise, education, and psychobehavioral support), new ideas regularly appear, stemming from studies aimed at providing proof of their efficacy and innocuousness, along with optimal modes of prescription and, at times, their cost-benefit ratio. This ongo...

Mitophagy: New Insight into the Cardiovascular Aging  

Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer’s Disease

The study of microglia, the immune cells of the brain, has experienced a renaissance after the discovery of microglia polarization. In fact, the concept that activated microglia can shift into the M1 pro-inflammatory or M2 neuroprotective phenotypes, depending on brain microenvironment, has completely changed the understanding of microglia in brain aging and neurodegenerative diseases. Microgli...

SkQ1 treatment and food restriction — two ways to retard an aging program of organisms

Effects of the mitochondria-targeted antioxidant SkQ1 and food restriction are compared. In both cases there is a remarkable increase in the median lifespan of organisms belonging to many different taxonomic ranks. Essentially, both SkQ1 treatment and restriction in food intake retard development of numerous adverse traits of senescence. This relationship could be predicted assuming that SkQ1 a...